“Engineering the Immune System as a New Tool for Cancer Therapy”
Lecture by Carl June, MD, Richard W. Vague Professor in Immunotherapy in the Department of Pathology and Laboratory Medicine, and Director of the Center for Cellular Immunotherapies at the Perelman School of Medicine, and Director of the Parker Institute for Cancer Immunotherapy at the University of Pennsylvania
Abstract: The quest to cure cancer has been one of the Holy Grails of medicine. The discovery Carl June will discuss, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. The notion of using the immune system to fight cancer is an old idea. Over a century ago bacteria were ground up and injected into patients with late-stage cancers in order to augment the immune system by a surgeon in New York City. However, we now have precise tools like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in a Darwinian fashion. June will discuss the promises and challenges faced by the evolving CAR T cell industry.